VSTM2A suppresses colorectal cancer and antagonizes Wnt signaling receptor LRP6

• Published in: Theranostics Vol. 9; no. 22; pp. 6517 - 6531
• Main Authors: Dong, Yujuan, Zhang, Yanquan, Kang, Wei, Wang, Guoping, Chen, Huarong, Higashimori, Akira, Nakatsu, Geicho, Go, Minnie, Tong, Joanna Hm, Zheng, Shu, To, Ka Fai, Sung, Joseph Jy, Yang, Xiaoyong, Ng, Simon Sm, Yu, Jun
• Format: Journal Article
• Language: English
• Published: Australia Ivyspring International Publisher Pty Ltd 01.01.2019; Ivyspring International Publisher
• Subjects: Antibodies; Cloning; Colorectal cancer; DNA methylation; Ethics; Gene expression; Patients; Proteins; Research Paper; Tumorigenesis; Tumors; Hong Kong; colorectal cancer prognosis; Wnt signaling; VSTM2A; LRP6

Hyperactivation of Wnt/β-catenin signaling pathway is a critical step in colorectal tumorigenesis. In this study, we identified that V-set and transmembrane domain containing 2A (VSTM2A) was a top-downregulated secreted protein that negatively regulated Wnt singling pathways in colorectal cancer (CR...