Effects of high fluoride drinking water on the cerebral function of mice

Objective: To study the effects after six months of exposure of mice to increasing concentrations of fluoride in drinking water (tap water, 10, 50, and 100 mg F/L) on their cerebral functions. Methods: Learning and memory abilities of high-fluoride exposed and control groups of mice were measured by...

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Published inFluoride Vol. 41; no. 2; pp. 148 - 151
Main Authors Sun, Z, Liu, F, Wu, L, Lu, Y, Yu, D
Format Journal Article
LanguageEnglish
Published 01.06.2008
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Abstract Objective: To study the effects after six months of exposure of mice to increasing concentrations of fluoride in drinking water (tap water, 10, 50, and 100 mg F/L) on their cerebral functions. Methods: Learning and memory abilities of high-fluoride exposed and control groups of mice were measured by a behavior-toxicological test (Shuttle-box Test), and the cholinesterase (ChE) activity in brain tissue homogenates of the mice was determined. Results: Learning and memory abilities of the fluoride-exposed groups were significantly lower than those of the control group, and the brain ChE activities of the fluoride-exposed groups were significantly higher. Conclusions: Elevated fluoride concentration in drinking water can decrease the cerebral functions of mice. Fluoride is a neurotoxicant.
AbstractList Objective: To study the effects after six months of exposure of mice to increasing concentrations of fluoride in drinking water (tap water, 10, 50, and 100 mg F/L) on their cerebral functions. Methods: Learning and memory abilities of high-fluoride exposed and control groups of mice were measured by a behavior-toxicological test (Shuttle-box Test), and the cholinesterase (ChE) activity in brain tissue homogenates of the mice was determined. Results: Learning and memory abilities of the fluoride-exposed groups were significantly lower than those of the control group, and the brain ChE activities of the fluoride-exposed groups were significantly higher. Conclusions: Elevated fluoride concentration in drinking water can decrease the cerebral functions of mice. Fluoride is a neurotoxicant.
Author Lu, Y
Yu, D
Wu, L
Liu, F
Sun, Z
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