Effects of high fluoride drinking water on the cerebral function of mice
Objective: To study the effects after six months of exposure of mice to increasing concentrations of fluoride in drinking water (tap water, 10, 50, and 100 mg F/L) on their cerebral functions. Methods: Learning and memory abilities of high-fluoride exposed and control groups of mice were measured by...
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| Published in | Fluoride Vol. 41; no. 2; pp. 148 - 151 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
01.06.2008
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| Online Access | Get full text |
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| Summary: | Objective: To study the effects after six months of exposure of mice to increasing concentrations of fluoride in drinking water (tap water, 10, 50, and 100 mg F/L) on their cerebral functions. Methods: Learning and memory abilities of high-fluoride exposed and control groups of mice were measured by a behavior-toxicological test (Shuttle-box Test), and the cholinesterase (ChE) activity in brain tissue homogenates of the mice was determined. Results: Learning and memory abilities of the fluoride-exposed groups were significantly lower than those of the control group, and the brain ChE activities of the fluoride-exposed groups were significantly higher. Conclusions: Elevated fluoride concentration in drinking water can decrease the cerebral functions of mice. Fluoride is a neurotoxicant. |
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| Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ISSN: | 0015-4725 |