Determining Amyloid-β Positivity Using 18F-AZD4694 PET Imaging

• Published in: The Journal of nuclear medicine (1978) Vol. 62; no. 2; p. 247
• Main Authors: Therriault, Joseph, Benedet, Andrea L, Pascoal, Tharick A, Savard, Melissa, Ashton, Nicholas J, Chamoun, Mira, Tissot, Cecile, Lussier, Firoza, Kang, Min Su, Bezgin, Gleb, Wang, Tina, Fernandes-Arias, Jaime, Massarweh, Gassan, Vitali, Paolo, Zetterberg, Henrik, Blennow, Kaj, Saha-Chaudhuri, Paramita, Soucy, Jean-Paul, Gauthier, Serge, Rosa-Neto, Pedro
• Format: Journal Article
• Language: English
• Published: New York Society of Nuclear Medicine 01.02.2021
• Subjects: 18F-AZD4694; Alzheimer disease; Alzheimer's disease; amyloid-β; Arbitration; Cerebellum; Cerebrospinal fluid; Classification; Clinical trials; Continuity (mathematics); Convergence; Dementia disorders; Deposition; Fluorine isotopes; Genotyping; Inspection; Magnetic resonance imaging; Medical imaging; Modelling; Neurodegenerative diseases; Neurosciences; Neurovetenskaper; Older people; PET; Positron emission; Psychiatry; Psykiatri; Senile plaques; Signs and symptoms; Substantia grisea; Tomography; Young adults

Amyloid-β deposition into plaques is a pathologic hallmark of Alzheimer disease appearing years before the onset of symptoms. Although cerebral amyloid-β deposition occurs on a continuum, dichotomization into positive and negative groups has advantages for diagnosis, clinical management, and populat...