Antcin A, a phytosterol regulates SARS‐CoV‐2 spike protein‐mediated metabolic alteration in THP‐1 cells explored by the 1H‐NMR‐based metabolomics approach

• Published in: Phytotherapy research Vol. 37; no. 3; pp. 885 - 902
• Main Authors: Dakpa, Gyaltsen, Senthil Kumar, Kanthasamy Jayabal, Tsao, Nai‐Wen, Wang, Sheng‐Yang
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.03.2023; Wiley Subscription Services, Inc
• Subjects: 1H‐NMR; ACE2; Acetic acid; Angiotensin-converting enzyme 2; antcin A; Chemical compounds; computer software; Coronaviruses; Cytotoxicity; Dexamethasone; Ethanolamine; Glutamine; humans; Metabolic pathways; Metabolism; Metabolites; Metabolomics; Methionine; Monocytes; NMR; Nuclear magnetic resonance; nuclear magnetic resonance spectroscopy; Perturbation; Pharmacology; Phenylalanine; Phosphoenolpyruvic acid; phytosterols; phytotherapy; Proteins; Receptors; SARS‐CoV‐2 spike protein; Severe acute respiratory syndrome; Severe acute respiratory syndrome coronavirus 2; Spike protein; Statistical analysis; Taiwanofungus camphoratus; toxicity testing

The mechanism of SARS‐CoV‐2 spike protein‐mediated perturbations of metabolic pathways and modulation of antcin A, a steroid‐like compound isolated from Taiwanofungus camphoratus, are not studied. Here, we investigated the metabolic alteration by SARS‐CoV‐2 spike protein and the regulatory effect of...