Early Immune Function and Duration of Organ Dysfunction in Critically Ill Children with Sepsis

• Published in: American journal of respiratory and critical care medicine Vol. 198; no. 3; pp. 361 - 369
• Main Authors: Muszynski, Jennifer A, Ramilo, Octavio, Hall, Mark W, Nofziger, Ryan, Moore-Clingenpeel, Melissa, Greathouse, Kristin, Anglim, Larissa, Steele, Lisa, Hensley, Josey, Hanson-Huber, Lisa, Nateri, Jyotsna
• Format: Journal Article
• Language: English
• Published: New York American Thoracic Society 01.08.2018
• Subjects: Children & youth; Confidence intervals; Critical care; Cytokines; Epidemiology; Hospitals; Hypotheses; Illnesses; Immune system; Intensive care; Mortality; Multiple organ dysfunction syndrome; Nosocomial infections; Pediatrics; Production capacity; Sepsis; Tumor necrosis factor-TNF

Because an intact immune response is important to help clear initial infection, prevent secondary infection, and prevent latent virus reactivation, immune function is likely highly relevant in sepsis. Healthy children were excluded if they had subjective or measured fever within the past 24 hours, h...