H2S‐Activated Ion‐Interference Therapy: A Novel Tumor Targeted Therapy Based on Copper‐Overload‐Mediated Cuproptosis and Pyroptosis

• Published in: Advanced functional materials Vol. 33; no. 38
• Main Authors: Zhao, Fan, Liang, Liying, Wang, Heng, Wang, Chen, Su, Dan, Yao, Ying, Li, Wangchang, Li, Juan, Zheng, Jingwu, Qiao, Liang, Mou, Xiaozhou, Che, Shenglei, Yu, Jing
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc 01.09.2023
• Subjects: Apoptosis; Cell death; Copper; Copper sulfides; Efflux; Homeostasis; Hydrogen sulfide; Interference; Materials science; Nanoparticles; Overloading; Proteins; Therapy; Tumors

Copper overload is a novel way to achieve copper‐ion‐interference therapy by disrupting copper homeostasis and treating diseases through multiple cell death pathways. However, it is difficult to reach copper overload since excess intracellular copper ions will be pumped out. Herein, copper overload...