Design and Synthesis of Rigid-Featured Tertiary Amine-Derived C2-Symmetric Chiral Furan-N,N′-dioxide Ligands

• Published in: European journal of organic chemistry Vol. 26; no. 42
• Main Authors: Chen, Zi-Yue, Hu, Pan, Wang, Xi-Rui, Xu, Ke-Lan, Wang, Yu-Heng, Tian, You-Ping, Zhou, Ying, Liu, Xiong-Li
• Format: Journal Article
• Language: English
• Published: WEINHEIM Wiley 07.11.2023; Wiley Subscription Services, Inc
• Subjects: Alkylation; Chemistry; Chemistry, Organic; Dioxides; Ligands; Nitrogen; Physical Sciences; Science & Technology; chiral N-oxides; CATALYSIS; IMINO ESTERS; SYMMETRY; PINCER LIGANDS; CONSTRUCTION; L-lprolinamides; SELECTIVE 3+2 CYCLOADDITION; chiral furan-N,N'-dioxideligands; N-OXIDES; Friedel-Crafts reaction; chiral furan-containing ligands

To expand the chemical space of chiral N-oxides and chiral furan-containing ligands, herein we designed and synthesized a new class of rigid-featured tertiary amine-derived C-2-symmetric chiral furan-N,N'-dioxide (Fu-2NO) ligands from optically pure lprolinamides/hydroxylprolinamides in operati...