NaOH-promoted reaction of 1,1-dihaloalkenes and 1H-azoles: synthesis of dihetaryl substituted alkenes

• Published in: New journal of chemistry Vol. 42; no. 21; pp. 17732 - 17739
• Main Authors: Zhang, Chen, Shi, Yu-Long, Zhang, Li-Yu, Yuan, Dong-Peng, Ban, Meng-Tao, Zheng, Jia-Yao, Liu, Deng-Hui, Guo, Shun-Na, Cui, Dong-Mei
• Format: Journal Article
• Language: English
• Published: CAMBRIDGE Royal Soc Chemistry 2018; Royal Society of Chemistry
• Subjects: Aliphatic compounds; Alkenes; Aromatic compounds; Chemical synthesis; Chemistry; Chemistry, Multidisciplinary; Crystallography; Ethers; Halogens; Heterocyclic compounds; Nitriles; Physical Sciences; Science & Technology; Sodium hydroxide; Substitutes; Triazoles; RUTHENIUM-CATALYZED SYNTHESIS; HALIDES; NUCLEOPHILES; CROSS-COUPLING REACTIONS; LIGANDS; PHENOLS; 1,1-DIBROMO-1-ALKENES; IMIDAZOLES; ULLMANN-TYPE REACTION; VINYL BROMIDES

An efficient NaOH-promoted synthesis of dihetaryl substituted alkenes from 1,1-dihaloalkenes and 1H-azoles under mild conditions has been developed. The reaction occurred in moderate to good yields and tolerated aliphatic, heterocyclic, and aryl substituted 1,1-dihaloalkenes containing functionaliti...