Age-related changes in regional cerebral blood flow among young to mid-life adults
Using PET with [(15)O]H2O, we examined age in relation to regional cerebral blood flow (rCBF) among young to mid-life adults. Previous work has largely contrasted rCBF between young and elderly age groups dichotomously. This study maps the continuum of normal age-related changes in rCBF from early t...
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Published in | Neuroreport Vol. 10; no. 12; p. 2493 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
England
20.08.1999
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Abstract | Using PET with [(15)O]H2O, we examined age in relation to regional cerebral blood flow (rCBF) among young to mid-life adults. Previous work has largely contrasted rCBF between young and elderly age groups dichotomously. This study maps the continuum of normal age-related changes in rCBF from early to mid-adulthood. We obtained images from 37 healthy volunteers between 19 and 50 years of age during an eyes-closed resting baseline condition. There was a negative correlation between age and rCBF in mesial frontal cortex, involving the anterior cingulate region (r = 0.63, p<0.001). These findings reflect differences in the distribution of rCBF evident in early to mid-adulthood that may be associated with subsequent changes in memory and executive functioning in later life. |
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AbstractList | Using PET with [(15)O]H2O, we examined age in relation to regional cerebral blood flow (rCBF) among young to mid-life adults. Previous work has largely contrasted rCBF between young and elderly age groups dichotomously. This study maps the continuum of normal age-related changes in rCBF from early to mid-adulthood. We obtained images from 37 healthy volunteers between 19 and 50 years of age during an eyes-closed resting baseline condition. There was a negative correlation between age and rCBF in mesial frontal cortex, involving the anterior cingulate region (r = 0.63, p<0.001). These findings reflect differences in the distribution of rCBF evident in early to mid-adulthood that may be associated with subsequent changes in memory and executive functioning in later life. |
Author | Boles Ponto, L L Watkins, G L Hichwa, R D O'Leary, D S Schultz, S K Andreasen, N C |
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Snippet | Using PET with [(15)O]H2O, we examined age in relation to regional cerebral blood flow (rCBF) among young to mid-life adults. Previous work has largely... |
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SubjectTerms | Adult Aging - physiology Cerebrovascular Circulation - physiology Humans Magnetic Resonance Imaging Middle Aged Reference Values Tomography, Emission-Computed |
Title | Age-related changes in regional cerebral blood flow among young to mid-life adults |
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