ALPHA-AMINO KETONES FROM AMINO-ACIDS AS PRECURSORS FOR THE KNORR PYRROLE SYNTHESIS

• Published in: Heterocycles Vol. 35; no. 2; pp. 843 - 850
• Main Authors: HAMBY, JM, HODGES, JC
• Format: Journal Article
• Language: English
• Published: OXFORD Elsevier 01.05.1993
• Subjects: Chemistry; Chemistry, Organic; Physical Sciences; Science & Technology; EFFICIENT SYNTHESIS; REACTIVITY; DERIVATIVES

A useful and versatile modification of the Knorr pyrrole synthesis is described. Key alpha-amino ketone intermediates for the Knorr condensation were readily prepared from the N-methoxy-N-methylamides of amino acids and condensed with 1,3-dicarbonyl compounds to afford tetrasubstituted pyrroles in g...