The protective effect of vitamins C and E against B(a)P-induced genotoxicity in human lymphocytes

• Published in: Journal of environmental pathology, toxicology and oncology Vol. 18; no. 3; p. 159
• Main Authors: Gajecka, M, Kujawski, L M, Gawecki, J, Szyfter, K
• Format: Journal Article
• Language: English
• Published: United States 1999
• Subjects: Adult; Antimutagenic Agents - pharmacology; Antioxidants - pharmacology; Ascorbic Acid - pharmacology; Benzo(a)pyrene - toxicity; Comet Assay; DNA Damage - drug effects; DNA Repair - drug effects; DNA Repair - genetics; Dose-Response Relationship, Drug; Female; Humans; Lymphocytes - drug effects; Mutagens - toxicity; Vitamin E - pharmacology

Polycyclic aromatic hydrocarbons (PAH) are a well-characterized group of mutagens and carcinogens. Benzo(a)pyrene [B(a)P], the best known compound in the group, exerts its genotoxic activity following metabolic activation, when it acquires the properties of an electrophilic reagent that is capable o...