Interaction of HIF-1α and Notch3 Is Required for the Expression of Carbonic Anhydrase 9 in Breast Carcinoma Cells

• Published in: Genes & cancer Vol. 4; no. 11-12; pp. 513 - 523
• Main Authors: Shareef, Mohammed M, Udayakumar, Thirupandiyur S, Sinha, Vishal K, Saleem, Shahid M, Griggs, Wendy W
• Format: Journal Article
• Language: English
• Published: United States SAGE Publications 01.11.2013
• Subjects: Original; hypoxia; CA9; VHL; PBX1; Notch3

Expression of carbonic anhydrase 9 (CA9) is associated with poor prognosis and increased tumor aggressiveness and does not always correlate with HIF-1α expression. Presently, we analyzed the regulation of CA9 expression during hypoxia by HIF-1α, Notch3, and the von Hippel-Lindau (VHL) in breast carc...