Gene-Based Analysis Reveals Sex-Specific Genetic Risk Factors of COPD

• Published in: AMIA ... Annual Symposium proceedings Vol. 2021; pp. 601 - 610
• Main Authors: Joo, Jaehyun, Himes, Blanca
• Format: Journal Article
• Language: English
• Published: United States American Medical Informatics Association 2021
• Subjects: Female; Genetic Predisposition to Disease; Genome-Wide Association Study - methods; Humans; Lung; Male; Polymorphism, Single Nucleotide; Pulmonary Disease, Chronic Obstructive - genetics; Risk Factors

Sex-specific differences have been noted among people with chronic obstructive pulmonary disease (COPD), but whether these differences are attributable to genetic variation is poorly understood. The availability of large biobanks with deeply phenotyped subjects such as the UK Biobank enables the inv...