TRH stimulation of in vivo GH release in the domestic fowl. Influence of TRH metabolites and effect of age on in vitro degradation of TRH

• Published in: Neuroendocrinology Vol. 40; no. 1; p. 33
• Main Authors: Scanes, C G, Harvey, S, Bolaffi, J L
• Format: Journal Article
• Language: English
• Published: Switzerland 01.01.1985
• Subjects: Age Factors; Animals; Chickens - metabolism; Growth Hormone - secretion; Male; Peptides, Cyclic - pharmacology; Piperazines - pharmacology; Pituitary Gland, Anterior - secretion; Pyrrolidonecarboxylic Acid - analogs & derivatives; Thyrotropin-Releasing Hormone - analogs & derivatives; Thyrotropin-Releasing Hormone - metabolism; Thyrotropin-Releasing Hormone - pharmacology

Thyrotropin-releasing hormone (TRH) stimulated in vivo growth hormone (GH) release in conscious and anesthetized young domestic fowl. The administration of the presumed metabolites of TRH, deamido-TRH (TRH-OH) and histidyl-proline diketopiperazine (HPD), was followed by small but significant (p less...