Prevalence of resistance of N. gonorrhoeae to penicillin and three other antibiotics in a rural area in Kenya

Of 90 isolates of Neisseria gonorrhoeae in a rural area in Kenya, 44 (48.9%) produced beta-lactamase (penicillinase). Testing for susceptibility of 35 penicillinase producing N. gonorrhoeae (PPNG) strains to four antibiotics yielded the following results: 16 (45.7%) showed a decreased susceptibility...

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Bibliographic Details
Published inEast African medical journal Vol. 68; no. 11; p. 853
Main Authors van Hall, M A, Petit, P L, van Hall, H N, Mouton, R P, Ndinya-Achola, J O
Format Journal Article
LanguageEnglish
Published Kenya 01.11.1991
Subjects
Drug Resistance, Microbial
Female
Gentamicins
Gonorrhea - drug therapy
Gonorrhea - epidemiology
Gonorrhea - microbiology
Humans
Kenya - epidemiology
Male
Penicillin Resistance
Population Surveillance
Prevalence
Rural Population
Spectinomycin - administration & dosage
Spectinomycin - therapeutic use
Tetracycline Resistance
Thiamphenicol - administration & dosage
Thiamphenicol - therapeutic use
Kenya
Drugs
Evaluation
Eastern Africa
Laboratory Examinations And Diagnoses
Africa
Treatment > complications
Infections
Gonorrhea
Kenya
English Speaking Africa
Examinations And Diagnoses
Diseases
Sexually Transmitted Diseases
Antibiotics
Rural Population
Population Characteristics
Reproductive Tract Infections
Population
Developing Countries
Africa South Of The Sahara
Demographic Factors
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Summary:Of 90 isolates of Neisseria gonorrhoeae in a rural area in Kenya, 44 (48.9%) produced beta-lactamase (penicillinase). Testing for susceptibility of 35 penicillinase producing N. gonorrhoeae (PPNG) strains to four antibiotics yielded the following results: 16 (45.7%) showed a decreased susceptibility to tetracycline; six (17.1%) showed resistance, probably plasmid mediated; 10 (28.6%) had intermediate susceptibility to gentamicin; one (2.9%) was resistant; and two (5.7%) isolates were resistant to cefotaxime. 16 (57.1%) of 28 non PPNG strains showed a decreased susceptibility to penicillin; 10 (35.7%) were resistant. Nine (32.1%) of 28 non-PPNG isolates showed intermediate susceptibility to tetracycline; one (3.6%) was resistant. Eight of non PPNG isolates (28.6%) showed decreased susceptibility to gentamicin. These results imply that penicillin and tetracycline should be abandoned as primary therapy. For the time being, thiamphenicol and spectinomycin seem to be good alternatives. The observation of cefotaxime resistance in N. gonorrhoeae in a rural area implies a warning concerning future possibilities for use of third generation cephalosporins.
ISSN:0012-835X