Expressional alterations and transcript isoforms of metastasis suppressor genes (KAI1 and KiSS1) in breast cancer patients
Metastasis suppressor genes are involved in the inhibition of a cancer cell's ability to metastasize. Down expression of such genes may contribute to pathogenesis of breast cancer. The aim of current study was firstly to evaluate expression of two examples, KAI1 and KISS1, and then to determine...
Saved in:
Published in | Asian Pacific journal of cancer prevention : APJCP Vol. 12; no. 10; p. 2785 |
---|---|
Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Thailand
2011
|
Subjects | |
Online Access | Get more information |
Cover
Loading…
Abstract | Metastasis suppressor genes are involved in the inhibition of a cancer cell's ability to metastasize. Down expression of such genes may contribute to pathogenesis of breast cancer. The aim of current study was firstly to evaluate expression of two examples, KAI1 and KISS1, and then to determine relationships with stages of breast cancer in a Pakistani population.
Fresh biopsy tissues were collected from different hospitals and oncology research institutes. The semi quantitative reverse transcriptase polymerase chain reaction was used to investigate KAI1 and KISS1 expression in 25 breast tumor tissues and 25 normal tissues. Statistical analysis was performed to explore its association with breast cancer risk.
The present study revealed that KAI1 and KISS1 mRNA expression was markedly reduced in tissues of breast cancer compared to adjacent normal tissue. In present study a splice variant of KAI1 during a screen for its expression analysis was also observed. This splice variant has not been reported previously.
Metastasis suppressor genes demonstrate reduced expression in breast cancers in Pakistan. |
---|---|
AbstractList | Metastasis suppressor genes are involved in the inhibition of a cancer cell's ability to metastasize. Down expression of such genes may contribute to pathogenesis of breast cancer. The aim of current study was firstly to evaluate expression of two examples, KAI1 and KISS1, and then to determine relationships with stages of breast cancer in a Pakistani population.
Fresh biopsy tissues were collected from different hospitals and oncology research institutes. The semi quantitative reverse transcriptase polymerase chain reaction was used to investigate KAI1 and KISS1 expression in 25 breast tumor tissues and 25 normal tissues. Statistical analysis was performed to explore its association with breast cancer risk.
The present study revealed that KAI1 and KISS1 mRNA expression was markedly reduced in tissues of breast cancer compared to adjacent normal tissue. In present study a splice variant of KAI1 during a screen for its expression analysis was also observed. This splice variant has not been reported previously.
Metastasis suppressor genes demonstrate reduced expression in breast cancers in Pakistan. |
Author | Rashid, R Mooez, S Zahid, A Kayani, M A Malik, F A Khan, A |
Author_xml | – sequence: 1 givenname: S surname: Mooez fullname: Mooez, S organization: Department of Biosciences, COMSATS Institute of Information and Technology, Islamabad, Pakistan – sequence: 2 givenname: F A surname: Malik fullname: Malik, F A – sequence: 3 givenname: M A surname: Kayani fullname: Kayani, M A – sequence: 4 givenname: R surname: Rashid fullname: Rashid, R – sequence: 5 givenname: A surname: Zahid fullname: Zahid, A – sequence: 6 givenname: A surname: Khan fullname: Khan, A |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/22320993$$D View this record in MEDLINE/PubMed |
BookMark | eNo1UF1LwzAUDaLonP4FuY_6UGiSNU0fx5g6NvBhCr6Nm_ZGAm0akgzUX2-ZChcOh_MF95qd-9HTGZuJRa2KWon3S3YlhBRl08gZ-15_hkgpudFjD9hnipgnkgB9BzmiT210IYNLox3jkGC0MFDGNJ1LkI7hlB8jfJCnBPfb5Yafwlu33_MHcB5MpMkPLfqWIoRpgHxON-zCYp_o9g_n7O1x_bp6LnYvT5vVclcEXutcdFyhVrXtUBjqpJSNEWphLddaKaUlL-tS2tJUJExbVZXUtjGTbjU3HBsu5uzutzcczUDdIUQ3YPw6_D9B_ACUO1iY |
ContentType | Journal Article |
DBID | CGR CUY CVF ECM EIF NPM |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) |
DatabaseTitleList | MEDLINE |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | no_fulltext_linktorsrc |
EISSN | 2476-762X |
ExternalDocumentID | 22320993 |
Genre | Journal Article |
GroupedDBID | CGR CUY CVF ECM EIF NPM |
ID | FETCH-LOGICAL-p178t-d16a867fda2bed3339b264ff1886668310703f0b5e2bc55538f9b4fff81b1a912 |
IngestDate | Sat Sep 18 10:45:59 EDT 2021 |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 10 |
Language | English |
LinkModel | OpenURL |
MergedId | FETCHMERGED-LOGICAL-p178t-d16a867fda2bed3339b264ff1886668310703f0b5e2bc55538f9b4fff81b1a912 |
PMID | 22320993 |
ParticipantIDs | pubmed_primary_22320993 |
PublicationCentury | 2000 |
PublicationDate | 2011-00-00 |
PublicationDateYYYYMMDD | 2011-01-01 |
PublicationDate_xml | – year: 2011 text: 2011-00-00 |
PublicationDecade | 2010 |
PublicationPlace | Thailand |
PublicationPlace_xml | – name: Thailand |
PublicationTitle | Asian Pacific journal of cancer prevention : APJCP |
PublicationTitleAlternate | Asian Pac J Cancer Prev |
PublicationYear | 2011 |
Score | 2.0921583 |
Snippet | Metastasis suppressor genes are involved in the inhibition of a cancer cell's ability to metastasize. Down expression of such genes may contribute to... |
SourceID | pubmed |
SourceType | Index Database |
StartPage | 2785 |
SubjectTerms | Base Sequence Biopsy Breast Neoplasms - genetics Down-Regulation Female Genes, Tumor Suppressor Humans Kangai-1 Protein - genetics Kisspeptins - genetics Molecular Sequence Data Pakistan Protein Isoforms - genetics RNA, Messenger - metabolism Sequence Analysis, DNA |
Title | Expressional alterations and transcript isoforms of metastasis suppressor genes (KAI1 and KiSS1) in breast cancer patients |
URI | https://www.ncbi.nlm.nih.gov/pubmed/22320993 |
Volume | 12 |
hasFullText | |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnZ3LT-MwEIetAhcuKxAsLC_5wIFVlVUdp3kcqwoEVEWIh9QbimNbirSbVDRI0DN_ODN20hjEisclqmw5h3zu5OfJPAg5FGD2peShx1OVekGitSe4Yp5O_FgEPNNZitnI44vw9DY4n_Qnnc6zE7X0UIk_2fzdvJLvUIUx4IpZsl8gu7gpDMBv4AtXIAzXTzE-fqzDWFFSmu_edWCbCYvEt5CxCd18VqI2ndmP6VUKihDrkMwepmZ9eY-NlK3_dTQ4Y2b5KL--ZugzyIuuwMj1CgPEMnXflGKdubp2YHIx6wg_txxFs6auFIV7DV2Rl-fDRWLZuCytG9txj__NjZU-aV2to_TJtp_qjtvBK2wFJdu4R9n6YxfuC2XMnB9EoQcmefLKJvvu3uu5FjayLX4cvNN_hi8IHcwD5h_Pvqmw3UwtkaUoRit5cTnGItH18JsDhxEeN2vkR31ioAOLf510VLFB5i566qCnwI626GmDnpaatuhpi54a9PQIwZvFBvxvmhfUYqcWIW2wb5Lbk-Ob4alXt9HwpiyKK0-yMI3DSMvUF0pyzhMBKlhrFsdwdsVGc2D1dU_0lS-yfh_egDoRMK_hRMPShPk_yXJRFmqb0JgFIotAgcZJFkg_EpIJ0fPhrmECYov_Ilv2Ud1Nba2Uu-Yh7vx3Zpestvtij6xo-HOqfVB6lTgwKF4ATwFc1g |
link.rule.ids | 786 |
linkProvider | National Library of Medicine |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Expressional+alterations+and+transcript+isoforms+of+metastasis+suppressor+genes+%28KAI1+and+KiSS1%29+in+breast+cancer+patients&rft.jtitle=Asian+Pacific+journal+of+cancer+prevention+%3A+APJCP&rft.au=Mooez%2C+S&rft.au=Malik%2C+F+A&rft.au=Kayani%2C+M+A&rft.au=Rashid%2C+R&rft.date=2011-01-01&rft.eissn=2476-762X&rft.volume=12&rft.issue=10&rft.spage=2785&rft_id=info%3Apmid%2F22320993&rft_id=info%3Apmid%2F22320993&rft.externalDocID=22320993 |