Viscum album L. extract and quercetin reduce cyclophosphamide-induced cardiotoxicity, urotoxicity and genotoxicity in mice

• Published in: Asian Pacific journal of cancer prevention : APJCP Vol. 12; no. 11; p. 2925
• Main Authors: Sekeroğlu, Vedat, Aydin, Birsen, Sekeroğlu, Zülal Atli
• Format: Journal Article
• Language: English
• Published: Thailand 2011
• Subjects: Animals; Bone Marrow - drug effects; Bone Marrow - pathology; Cardiotonic Agents; Cardiotoxins - toxicity; Catalase - metabolism; Chromosome Aberrations - chemically induced; Chromosome Aberrations - drug effects; Cyclophosphamide - pharmacology; Cyclophosphamide - toxicity; DNA Damage - drug effects; Female; Glutathione - metabolism; Glutathione Peroxidase - metabolism; Glutathione Transferase - metabolism; Heart - drug effects; Heart Diseases - chemically induced; Heart Diseases - drug therapy; Male; Mice; Mitotic Index; Mutagens - toxicity; Myocardium - pathology; Oxidative Stress - drug effects; Plant Extracts - administration & dosage; Plant Extracts - pharmacology; Quercetin - pharmacology; Superoxide Dismutase - metabolism; Urinary Bladder - drug effects; Urinary Bladder - pathology; Viscum album

Possible protective effects of a methanolic extract of Viscum album (VA) and quercetin (QE) against cyclophosphamide (CP) induced cardiotoxicity, urotoxicity and genotoxicity in mice were evaluated. Mice were administered orally VA (250 mg/kg/day) and QE (50 mg/kg/day) for 10 days alone or in combin...