Morphological and functional consequences and quality of life following severe acute pancreatitis

In this study, we evaluated pancreatic morphology and function as well as nutritional status and quality of life among patients who experienced severe acute pancreatitis (SAP). We enrolled 99 patients with SAP and 51 with mild acute pancreatitis (MAP). Computed tomography was performed one year foll...

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Bibliographic Details
Published inAnnali italiani di chirurgia Vol. 6; p. 403
Main Authors Koziel, Dorota, Suliga, Edyta, Grabowska, Urszula, Gluszek, Stanislaw
Format Journal Article
LanguageEnglish
Published Italy 01.09.2017
Subjects
Acute Disease
Adult
Aged
Exocrine Pancreatic Insufficiency - etiology
Female
Humans
Male
Malnutrition - etiology
Middle Aged
Pancreas - pathology
Pancreatitis - complications
Pancreatitis - diagnostic imaging
Pancreatitis - physiopathology
Pancreatitis - surgery
Postoperative Complications - etiology
Quality of Life
Registries
Tomography, X-Ray Computed
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Summary:In this study, we evaluated pancreatic morphology and function as well as nutritional status and quality of life among patients who experienced severe acute pancreatitis (SAP). We enrolled 99 patients with SAP and 51 with mild acute pancreatitis (MAP). Computed tomography was performed one year following the disease. Endocrine function was evaluated by measuring hemoglobin A1c, insulin, and C peptide levels. Pancreatic exocrine insufficiency (PEI) was diagnosed by the concentration of fecal elastase-1. Nutritional status was assessed according to anthropometric parameters, albumin levels in blood serum, and the total number of lymphocytes. Quality of life was investigated using the Health Survey Questionnaire (SF-36). PEI was observed in 17.2% of patients after SAP vs. 7.8% of patients after MAP (p>0.05). Endocrine insufficiency was noted in 18.6% of patients after AP vs. 4.3% of patients after MAP (p<0.05). We observed changes in pancreatic morphology in 52.5% of patients after SAP and 9.8% of patients after MAP (p<0.0001). A medium risk of malnutrition was observed in 16.2% of patients after AP vs. 2% of patients after MAP (p=0.01). Patients with SAP described their mental health in more negative terms than patients with MAP (p<0.05). One year after SAP, patients exhibited changes in pancreatic morphology and carbohydrate metabolism disorders, and exocrine insufficiency occurred with a similar frequency. The majority of quality of life domains did not differ between patient groups. Acute pancreatitis, Pancreatic morphology, Pancreatic function.
ISSN:2239-253X