Preventive effects of procyanidin A2 on glucose homeostasis, pancreatic and duodenal homebox 1, and glucose transporter 2 gene expression disturbance induced by bisphenol A in male mice

• Published in: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society Vol. 67; no. 2; p. 243
• Main Authors: Ahangarpour, A, Afshari, G, Mard, S A, Khodadadi, A, Hashemitabar, M
• Format: Journal Article
• Language: English
• Published: Poland 01.04.2016
• Subjects: Animals; Apoptosis - drug effects; Benzhydryl Compounds - pharmacology; Blood Glucose - analysis; Catechin - pharmacology; Catechin - therapeutic use; Cells, Cultured; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - chemically induced; Diabetes Mellitus, Type 2 - drug therapy; Diabetes Mellitus, Type 2 - metabolism; Gene Expression - drug effects; Glucose Transporter Type 2 - genetics; Homeodomain Proteins - genetics; Homeostasis - drug effects; Hyperglycemia - blood; Hyperglycemia - chemically induced; Hyperglycemia - drug therapy; Hyperglycemia - metabolism; Insulin - blood; Islets of Langerhans - drug effects; Male; Malondialdehyde - blood; Mice; Phenols - pharmacology; Proanthocyanidins - pharmacology; Proanthocyanidins - therapeutic use; RNA, Messenger - metabolism; Trans-Activators - genetics

Procyanidins (PCs) as oligomeric compounds with antidiabetic properties formed from catechin and epicatechin molecules. Bisphenol A(BPA) is a common chemical material use in food and beverage packaging. The aim of this study was to explore the protective effects of procyanidin A2 (PCA2) against gluc...