A serine/threonine kinase, Cot/Tpl2, modulates bacterial DNA–induced IL-12 production and Th cell differentiation

• Published in: The Journal of clinical investigation Vol. 114; no. 6; pp. 857 - 866
• Main Authors: Sugimoto, Kenji, Ohata, Mutsuhiro, Miyoshi, Jun, Ishizaki, Hiroyoshi, Tsuboi, Naotake, Masuda, Akio, Yoshikai, Yasunobu, Takamoto, Masaya, Sugane, Kazuo, Matsuo, Seiichi, Shimada, Yasuhiro, Matsuguchi, Tetsuya
• Format: Journal Article
• Language: English
• Published: American Society for Clinical Investigation 15.09.2004

A serine/threonine protein kinase, Cot/Tpl2, is indispensable for extracellular signal–regulated kinase (ERK) activation and production of TNF-α and PGE 2 in LPS-stimulated macrophages. We show here that Cot/Tpl2 is also activated by other Toll-like receptor (TLR) ligands. Bacterial DNA rich in the...