CD11chigh B Cell Expansion Is Associated With Severity and Brain Atrophy in Neuromyelitis Optica

• Published in: Neurology : neuroimmunology & neuroinflammation Vol. 11; no. 2; p. e200206
• Main Authors: Amano, Eiichiro, Sato, Wakiro, Kimura, Yukio, Kimura, Atsuko, Lin, Youwei, Okamoto, Tomoko, Sato, Noriko, Yokota, Takanori, Yamamura, Takashi
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 01.03.2024

Neuromyelitis optica (NMO) is an autoimmune astrocytopathy mediated by anti-AQP4 antibody-producing B cells. Recently, a B-cell subset highly expressing CD11c and T-bet, originally identified as age-associated B cells, has been shown to be involved in the pathogenesis of various autoimmune diseases....