Sequencing and promoter analysis of the genomic region between the rat neuronal nicotinic acetylcholine receptor beta 4 and alpha 3 genes

• Published in: Journal of neurobiology Vol. 25; no. 8; p. 960
• Main Author: Boyd, R T
• Format: Journal Article
• Language: English
• Published: United States 01.08.1994
• Subjects: Animals; Base Sequence; DNA - analysis; Electrophoresis, Polyacrylamide Gel; Electrophysiology; Genome; Luciferases - genetics; Molecular Sequence Data; Nucleic Acid Hybridization; PC12 Cells; Promoter Regions, Genetic - genetics; Rats; Receptors, Nicotinic - genetics; RNA - analysis; Transcription, Genetic - physiology; Transfection

Nicotinic acetylcholine receptors (nAChRs) found on neurons are composed of ligand binding (alpha) and structural (beta) subunits. Different combinations of alpha and beta subunits produce nAChR subtypes with different pharmacological and ion-conducting properties. Transcriptional regulation may be...