Clinical Exploration and Physiologically Based Modelling of the Impact of Hepatic Impairment on Entrectinib Pharmacokinetics - Ozbey, Agustos C; Meneses-Lorente, Georgina; Simmons, Brian; McCallum, Sam; Annaert, Pieter; Parrott, Neil; Umehara, Kenichi (Clinical pharmacokinetics, 2025)
Keywords: Administration, Oral; Adult; Aged; Area Under Curve; Benzamides - administration & dosage; Benzamides - blood; Benzamides - pharmacokinetics; Bile; Clinical trials; Computer Simulation; Cytochrome P-450 CYP3A - metabolism; Drug dosages; Enzymes; Female; Humans; Indazoles - administration & dosage; Indazoles - blood; Indazoles - pharmacokinetics; Kinases; Liver; Liver Diseases - blood; Liver Diseases - metabolism; Male; Metabolism; Metabolites; Middle Aged; Models, Biological; Permeability; Pharmacokinetics; Plasma; Simulation; Trends; Tumors