Inhibitory Subpopulations in preBötzinger Complex Play Distinct Roles in Modulating Inspiratory Rhythm and Pattern

• Published in: The Journal of neuroscience Vol. 44; no. 25; p. 1
• Main Authors: Chang, Zheng, Skach, Jordan, Kam, Kaiwen
• Format: Journal Article
• Language: English
• Published: United States Society for Neuroscience 19.06.2024
• Subjects: Amplitudes; Animals; Animals, Newborn; Brain slice preparation; Dbx1 protein; Female; Glutamate Decarboxylase - genetics; Glutamate Decarboxylase - metabolism; Glutamatergic transmission; Glycine Plasma Membrane Transport Proteins - genetics; Glycine Plasma Membrane Transport Proteins - metabolism; Glycine transporter; Inhalation - physiology; Latency; Male; Medulla Oblongata - cytology; Medulla Oblongata - physiology; Mice; Mice, Transgenic; Neonates; Neural Inhibition - physiology; Neural networks; Neurogenesis; Neurons; Neurons - physiology; Patterning; Periodicity; Photoactivation; Respiration; Respiratory Center - cytology; Respiratory Center - physiology; Rhythm; Rhythms; Spatial distribution; Stimulation; Subpopulations; γ-Aminobutyric acid; inhibition; motor systems; breathing; central pattern generator

Inhibitory neurons embedded within mammalian neural circuits shape breathing, walking, and other rhythmic motor behaviors. At the core of the neural circuit controlling breathing is the preBötzinger Complex (preBötC), where GABAergic (GAD1/2 ) and glycinergic (GlyT2 ) neurons are functionally and an...