Hominoid-specific enzyme GLUD2 promotes growth of IDH1R132H glioma

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 111; no. 39; pp. 14217 - 14222
• Main Authors: Chen, Ruihuan, Nishimura, Merry C, Kharbanda, Samir, Peale, Frank, Deng, Yuzhong, Daemen, Anneleen, Forrest, William F, Kwong, Mandy, Hedehus, Maj, Hatzivassiliou, Georgia, Friedman, Lori S, Phillips, Heidi S
• Format: Journal Article
• Language: English
• Published: United States National Acad Sciences 30.09.2014; National Academy of Sciences
• Subjects: alpha-ketoglutaric acid; Amino Acid Substitution; Animals; Biological Sciences; Brain Neoplasms - enzymology; Brain Neoplasms - genetics; Brain Neoplasms - pathology; carcinogenesis; Cell Line, Tumor; cognition; cortex; Female; Gene Knockdown Techniques; Genes, p53; Glioma - enzymology; Glioma - genetics; Glioma - pathology; Glutamate Dehydrogenase - antagonists & inhibitors; Glutamate Dehydrogenase - genetics; Glutamate Dehydrogenase - metabolism; glutamic acid; Glutamic Acid - metabolism; Humans; isocitrate dehydrogenase; Isocitrate Dehydrogenase - genetics; Isocitrate Dehydrogenase - metabolism; Mice; Mice, Inbred NOD; Mice, Nude; Mice, SCID; Mutant Proteins - genetics; Mutant Proteins - metabolism; mutation; neocortex; neoplasms; Neoplastic Stem Cells - enzymology; Neoplastic Stem Cells - pathology; Receptors, Glutamate - genetics; Receptors, Glutamate - metabolism; stem cells; astrocytoma; tumor metabolism; oligodendroglioma

Somatic mutation of isocitrate dehydrogenase 1 (IDH1) is now recognized as the most common initiating event for secondary glioblastoma, a brain tumor type arising with high frequency in the frontal lobe. A puzzling feature of IDH1 mutation is the selective manifestation of glioma as the only neoplas...