Hominoid-specific enzyme GLUD2 promotes growth of IDH1R132H glioma - Chen, Ruihuan; Nishimura, Merry C; Kharbanda, Samir; Peale, Frank; Deng, Yuzhong; Daemen, Anneleen; Forrest, William F; Kwong, Mandy; Hedehus, Maj; Hatzivassiliou, Georgia; Friedman, Lori S; Phillips, Heidi S (Proceedings of the National Academy of Sciences - PNAS, 2014)
Keywords: alpha-ketoglutaric acid; Amino Acid Substitution; Animals; Biological Sciences; Brain Neoplasms - enzymology; Brain Neoplasms - genetics; Brain Neoplasms - pathology; carcinogenesis; Cell Line, Tumor; cognition; cortex; Female; Gene Knockdown Techniques; Genes, p53; Glioma - enzymology; Glioma - genetics; Glioma - pathology; Glutamate Dehydrogenase - antagonists & inhibitors; Glutamate Dehydrogenase - genetics; Glutamate Dehydrogenase - metabolism; glutamic acid; Glutamic Acid - metabolism; Humans; isocitrate dehydrogenase; Isocitrate Dehydrogenase - genetics; Isocitrate Dehydrogenase - metabolism; Mice; Mice, Inbred NOD; Mice, Nude; Mice, SCID; Mutant Proteins - genetics; Mutant Proteins - metabolism; mutation; neocortex; neoplasms; Neoplastic Stem Cells - enzymology; Neoplastic Stem Cells - pathology; Receptors, Glutamate - genetics; Receptors, Glutamate - metabolism; stem cells; astrocytoma; tumor metabolism; oligodendroglioma