Serum interleukin-6 and fever at diagnosis in children with acute leukemia

• Published in: The American journal of pediatric hematology/oncology Vol. 15; no. 2; p. 239
• Main Authors: Minamishima, I, Ohga, S, Ishii, E, Matsuzaki, A, Kai, T, Akazawa, K, Ueda, K
• Format: Journal Article
• Language: English
• Published: United States 01.05.1993
• Subjects: Adolescent; Child; Fever - blood; Fever - etiology; Humans; Interleukin-6 - blood; Leukemia, Myeloid, Acute - blood; Leukemia, Myeloid, Acute - complications; Leukemia, Myeloid, Acute - diagnosis; Precursor Cell Lymphoblastic Leukemia-Lymphoma - blood; Precursor Cell Lymphoblastic Leukemia-Lymphoma - complications; Precursor Cell Lymphoblastic Leukemia-Lymphoma - diagnosis; Tumor Necrosis Factor-alpha - metabolism

We examined serum interleukin (IL)-6 and tumor necrosis factor (TNF) alpha levels at initial diagnosis in acute leukemic children in order to clarify the roles of these cytokines on the febrile and hematological responses in the disease. IL-6 levels were significantly higher in 34 leukemic children...