Beta S haplotypes in various world populations

• Published in: Human genetics Vol. 89; no. 1; p. 99
• Main Authors: Oner, C, Dimovski, A J, Olivieri, N F, Schiliro, G, Codrington, J F, Fattoum, S, Adekile, A D, Oner, R, Yüregir, G T, Altay, C
• Format: Journal Article
• Language: English
• Published: Germany 01.04.1992
• Subjects: Africa; Anemia, Sickle Cell - blood; Anemia, Sickle Cell - genetics; Asia; Base Sequence; Genetic Testing; Globins - genetics; Haplotypes; Hemoglobin SC Disease - blood; Hemoglobin SC Disease - genetics; Humans; Molecular Sequence Data; Mutation - genetics; Oligodeoxyribonucleotides - genetics; Polymerase Chain Reaction; Promoter Regions, Genetic - genetics; Sickle Cell Trait - blood; Sickle Cell Trait - genetics; Thalassemia - blood; Thalassemia - genetics; United States; Asia; United States; Africa

We have determined the beta S haplotypes in 709 patients with sickle cell anemia, 30 with SC disease, 91 with S-beta-thalassemia, and in 322 Hb S heterozygotes from different countries. The methodology concerned the detection of mutations in the promoter sequences of the G gamma- and A gamma-globin...