Role of renin-angiotensin system in cardiopulmonary bypass hypertension
The role of the renin-angiotensin system in the aetiology of perioperative hypertension was studied in 15 previously normotensive patients undergoing coronary artery surgery and anaesthetized with fentanyl. Measurements of plasma renin activity were made at intervals before and during cardiopulmonar...
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Published in | Canadian Anaesthetists' Society journal Vol. 31; no. 2; pp. 160 - 165 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Toronto, ON
Canadian Anaesthetists' Society
01.03.1984
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Subjects | |
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Abstract | The role of the renin-angiotensin system in the aetiology of perioperative hypertension was studied in 15 previously normotensive patients undergoing coronary artery surgery and anaesthetized with fentanyl. Measurements of plasma renin activity were made at intervals before and during cardiopulmonary bypass (CPB). In addition, angiotensin II blockade with saralasin was used in an attempt to treat hypertension during CPB. Nine of the patients became hypertensive (increase in systemic pressure of more than 20 per cent) before CPB and although the mean plasma renin activity was higher in this group than in the normotensive patients it was within normal limits for each group. Hypertension during CPB (mean blood pressure greater than 100 mmHg at 1.8 l X m-2 flow), occurred in seven patients but was not associated with increased renin activity and did not respond to saralasin in doses up to 20 micrograms X kg-1 X min-1. It is concluded that cardiopulmonary bypass associated hypertension is not mediated by activation of the renin-angiotensin system. |
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AbstractList | The role of the renin-angiotensin system in the aetiology of perioperative hypertension was studied in 15 previously normotensive patients undergoing coronary artery surgery and anaesthetized with fentanyl. Measurements of plasma renin activity were made at intervals before and during cardiopulmonary bypass (CPB). In addition, angiotensin II blockade with saralasin was used in an attempt to treat hypertension during CPB. Nine of the patients became hypertensive (increase in systemic pressure of more than 20 per cent) before CPB and although the mean plasma renin activity was higher in this group than in the normotensive patients it was within normal limits for each group. Hypertension during CPB (mean blood pressure greater than 100 mmHg at 1.8 l X m-2 flow), occurred in seven patients but was not associated with increased renin activity and did not respond to saralasin in doses up to 20 micrograms X kg-1 X min-1. It is concluded that cardiopulmonary bypass associated hypertension is not mediated by activation of the renin-angiotensin system. |
Author | WHALLEY, D. G BEVAN, D. R WYNANDS, J. E WONG, P TOWNSEND, G. E |
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Keywords | Cardiopulmonary bypass Human Hypertension Renin angiotensin system Surgery Coronary artery Anesthesia |
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SubjectTerms | Anesthesia Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Angiotensin II - antagonists & inhibitors Biological and medical sciences Cardiopulmonary Bypass - adverse effects Female General anesthesia. Technics. Complications. Neuromuscular blocking. Premedication. Surgical preparation. Sedation Humans Hypertension - drug therapy Hypertension - etiology Male Medical sciences Middle Aged Renin - blood Renin-Angiotensin System Saralasin - therapeutic use Vascular Resistance |
Title | Role of renin-angiotensin system in cardiopulmonary bypass hypertension |
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