Pulmonary lymphoid neogenesis in idiopathic pulmonary arterial hypertension

• Published in: American journal of respiratory and critical care medicine Vol. 185; no. 3; p. 311
• Main Authors: Perros, Frédéric, Dorfmüller, Peter, Montani, David, Hammad, Hamida, Waelput, Wim, Girerd, Barbara, Raymond, Nicolas, Mercier, Olaf, Mussot, Sacha, Cohen-Kaminsky, Sylvia, Humbert, Marc, Lambrecht, Bart N
• Format: Journal Article
• Language: English
• Published: United States American Thoracic Society 01.02.2012
• Subjects: Adaptive Immunity; Adult; Antibodies; Case-Control Studies; Chemokines; Chemokines - metabolism; Choristoma - metabolism; Choristoma - pathology; Connective tissue; Cytokines; Cytokines - metabolism; Dendritic cells; Disease; Eisenmenger Complex - complications; Familial Primary Pulmonary Hypertension; Female; Flow Cytometry; Fluorescent Antibody Technique; Follicles; Growth factors; Humans; Hypertension, Pulmonary - immunology; Hypertension, Pulmonary - metabolism; Hypertension, Pulmonary - pathology; Immune system; Immunoglobulins; Lungs; Lymphocytes; Lymphoid Tissue - metabolism; Lymphoid Tissue - pathology; Male; Patients; Platelet-Derived Growth Factor - metabolism; Polymerase chain reaction; Pulmonary arteries; Pulmonary hypertension; Real-Time Polymerase Chain Reaction; T-Lymphocytes - metabolism; Belgium; France

Patients with idiopathic pulmonary arterial hypertension (IPAH) present circulating autoantibodies against vascular wall components. Pathogenic antibodies may be generated in tertiary (ectopic) lymphoid tissues (tLTs). To assess the frequency of tLTs in IPAH lungs, as compared with control subjects...