Voltage-gated ion channels

• Published in: Handbook of experimental pharmacology no. 182; p. 85
• Main Author: Nau, C
• Format: Journal Article
• Language: English
• Published: Germany 2008
• Subjects: Anesthetics, General - pharmacology; Animals; Central Nervous System - drug effects; Central Nervous System - metabolism; Cyclic Nucleotide-Gated Cation Channels - drug effects; Humans; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Ion Channel Gating - drug effects; Ion Channels - chemistry; Ion Channels - drug effects; Ion Channels - metabolism; Membrane Potentials - drug effects; Models, Molecular; Potassium Channels - drug effects; Potassium Channels, Tandem Pore Domain - drug effects; Protein Conformation; Sodium Channels - drug effects

How and where simple volatile organic molecules act in the central nervous system to cause loss of consciousness and insensitivity to pain has eluded investigation; yet remarkable progress has been made recently towards identifying possible molecular targets through which the mechanism of anesthesia...