Extracellular Vesicles and Their Emerging Roles as Cellular Messengers in Endocrinology: An Endocrine Society Scientific Statement
During the last decade, there has been great interest in elucidating the biological role of extracellular vesicles (EVs), particularly, their hormone-like role in cell-to-cell communication. The field of endocrinology is uniquely placed to provide insight into the functions of EVs, which are secrete...
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Published in | Endocrine reviews Vol. 43; no. 3; pp. 441 - 468 |
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Main Authors | , , , , , , , , , , , |
Format | Journal Article |
Language | English |
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United States
Oxford University Press
21.04.2022
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Abstract | During the last decade, there has been great interest in elucidating the biological role of extracellular vesicles (EVs), particularly, their hormone-like role in cell-to-cell communication. The field of endocrinology is uniquely placed to provide insight into the functions of EVs, which are secreted from all cells into biological fluids and carry endocrine signals to engage in paracellular and distal interactions. EVs are a heterogeneous population of membrane-bound vesicles of varying size, content, and bioactivity. EVs are specifically packaged with signaling molecules, including lipids, proteins, and nucleic acids, and are released via exocytosis into biofluid compartments. EVs regulate the activity of both proximal and distal target cells, including translational activity, metabolism, growth, and development. As such, EVs signaling represents an integral pathway mediating intercellular communication. Moreover, as the content of EVs is cell-type specific, it is a "fingerprint" of the releasing cell and its metabolic status. Recently, changes in the profile of EV and bioactivity have been described in several endocrine-related conditions including diabetes, obesity, cardiovascular diseases, and cancer. The goal of this statement is to highlight relevant aspects of EV research and their potential role in the field of endocrinology. |
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AbstractList | During the last decade, there has been great interest in elucidating the biological role of extracellular vesicles (EVs), particularly, their hormone-like role in cell-to-cell communication. The field of endocrinology is uniquely placed to provide insight into the functions of EVs, which are secreted from all cells into biological fluids and carry endocrine signals to engage in paracellular and distal interactions. EVs are a heterogeneous population of membrane-bound vesicles of varying size, content, and bioactivity. EVs are specifically packaged with signaling molecules, including lipids, proteins, and nucleic acids, and are released via exocytosis into biofluid compartments. EVs regulate the activity of both proximal and distal target cells, including translational activity, metabolism, growth, and development. As such, EVs signaling represents an integral pathway mediating intercellular communication. Moreover, as the content of EVs is cell-type specific, it is a “fingerprint” of the releasing cell and its metabolic status. Recently, changes in the profile of EV and bioactivity have been described in several endocrine-related conditions including diabetes, obesity, cardiovascular diseases, and cancer. The goal of this statement is to highlight relevant aspects of EV research and their potential role in the field of endocrinology. |
Author | Kiang Lim, Sai Wang, Qun Das, Saumya Weaver, Alissa M Rice, Gregory E Erdbrügger, Uta Kalluri, Raghu Sahoo, Susmita Salomon, Carlos Andy Tao, W Vader, Pieter Olefsky, Jerrold M |
Author_xml | – sequence: 1 givenname: Carlos orcidid: 0000-0003-4474-0046 surname: Salomon fullname: Salomon, Carlos organization: Exosome Biology Laboratory, Centre for Clinical Diagnostics, University of Queensland Centre for Clinical Research, Royal Brisbane and Women's Hospital, Faculty of Medicine, The University of Queensland, Brisbane, Australia – sequence: 2 givenname: Saumya orcidid: 0000-0002-4521-4606 surname: Das fullname: Das, Saumya organization: Cardiovascular Research Center of Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA – sequence: 3 givenname: Uta surname: Erdbrügger fullname: Erdbrügger, Uta organization: Department of Medicine, Nephrology Division, University of Virginia, Charlottesville, VA, USA – sequence: 4 givenname: Raghu surname: Kalluri fullname: Kalluri, Raghu organization: Department of Cancer Biology, Metastasis Research Center, University of Texas MD Anderson Cancer Center, Houston, TX, USA – sequence: 5 givenname: Sai orcidid: 0000-0002-5752-3297 surname: Kiang Lim fullname: Kiang Lim, Sai organization: Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore – sequence: 6 givenname: Jerrold M orcidid: 0000-0003-0392-1705 surname: Olefsky fullname: Olefsky, Jerrold M organization: Department of Medicine, University of California-San Diego, La Jolla, CA, USA – sequence: 7 givenname: Gregory E orcidid: 0000-0001-7177-0246 surname: Rice fullname: Rice, Gregory E organization: Inoviq Limited, Notting Hill, Australia – sequence: 8 givenname: Susmita orcidid: 0000-0002-7279-1564 surname: Sahoo fullname: Sahoo, Susmita organization: Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA – sequence: 9 givenname: W orcidid: 0000-0002-5535-5517 surname: Andy Tao fullname: Andy Tao, W organization: Department of Biochemistry, Purdue University, West Lafayette, IN, USA – sequence: 10 givenname: Pieter orcidid: 0000-0002-7059-8920 surname: Vader fullname: Vader, Pieter organization: CDL Research, Division LAB, UMC Utrecht, Utrecht, the Netherlands Faculty of Medicine, Utrecht University, Utrecht, the Netherlands; Laboratory of Experimental Cardiology, UMC Utrecht, Utrecht, The Netherlands – sequence: 11 givenname: Qun orcidid: 0000-0002-2841-2651 surname: Wang fullname: Wang, Qun organization: Key Laboratory of Infection and Immunity of Shandong Province, Department of Immunology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China – sequence: 12 givenname: Alissa M surname: Weaver fullname: Weaver, Alissa M organization: Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA |
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Copyright | The Author(s) 2022. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. The Author(s) 2022. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com 2022 |
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Keywords | microvesicle apoptotic body signaling cellular messenger biogenesis migrasome exosome extracellular vesicle ectosome oncosome |
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Title | Extracellular Vesicles and Their Emerging Roles as Cellular Messengers in Endocrinology: An Endocrine Society Scientific Statement |
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