Ly6Chigh Monocytes Protect against Kidney Damage during Sepsis via a CX3CR1-Dependent Adhesion Mechanism

• Published in: Journal of the American Society of Nephrology Vol. 27; no. 3; pp. 792 - 803
• Main Authors: Chousterman, Benjamin G, Boissonnas, Alexandre, Poupel, Lucie, Baudesson de Chanville, Camille, Adam, Julien, Tabibzadeh, Nahid, Licata, Fabrice, Lukaszewicz, Anne-Claire, Lombès, Amélie, Deterre, Philippe, Payen, Didier, Combadière, Christophe
• Format: Journal Article
• Language: English
• Published: United States American Society of Nephrology 01.03.2016
• Subjects: Acute Kidney Injury - etiology; Acute Kidney Injury - pathology; Acute Kidney Injury - prevention & control; Acute-Phase Reaction - immunology; Adoptive Transfer; Alleles; Animals; Antigens, Ly - analysis; Basic Research; Cell Adhesion - genetics; Cell Movement; CX3C Chemokine Receptor 1; Endothelium, Vascular - metabolism; Genotype; Humans; Intravital Microscopy; Male; Mice; Mice, Inbred C57BL; Microscopy, Fluorescence, Multiphoton; Monocytes - chemistry; Monocytes - physiology; Monocytes - transplantation; Polymorphism, Genetic; Receptors, Chemokine - genetics; Receptors, Chemokine - metabolism; Receptors, Interleukin-1 - antagonists & inhibitors; Sepsis - complications; immunology; kidney dysfunction; chemokine receptor

Monocytes have a crucial role in both proinflammatory and anti-inflammatory phenomena occurring during sepsis. Monocyte recruitment and activation are orchestrated by the chemokine receptors CX3CR1 and CCR2 and their cognate ligands. However, little is known about the roles of these cells and chemok...