A unique androgen excess signature in idiopathic intracranial hypertension is linked to cerebrospinal fluid dynamics

• Published in: JCI insight Vol. 4; no. 6
• Main Authors: O'Reilly, Michael W, Westgate, Connar Sj, Hornby, Catherine, Botfield, Hannah, Taylor, Angela E, Markey, Keira, Mitchell, James L, Scotton, William J, Mollan, Susan P, Yiangou, Andreas, Jenkinson, Carl, Gilligan, Lorna C, Sherlock, Mark, Gibney, James, Tomlinson, Jeremy W, Lavery, Gareth G, Hodson, David J, Arlt, Wiebke, Sinclair, Alexandra J
• Format: Journal Article
• Language: English
• Published: United States American Society for Clinical Investigation 21.03.2019
• Subjects: Adult; Androgens - blood; Androgens - urine; Animals; Female; Humans; Hydrodynamics; Intracranial Hypertension; Obesity; Polycystic Ovary Syndrome - metabolism; Pseudotumor Cerebri - cerebrospinal fluid; Pseudotumor Cerebri - metabolism; Rats; Testosterone - blood; Neuroscience; Endocrinology; Neurological disorders

Idiopathic intracranial hypertension (IIH) is a condition of unknown etiology, characterized by elevated intracranial pressure frequently manifesting with chronic headaches and visual loss. Similar to polycystic ovary syndrome (PCOS), IIH predominantly affects obese women of reproductive age. In thi...