Osteopontin RNA aptamer can prevent and reverse pressure overload-induced heart failure

• Published in: Cardiovascular research Vol. 113; no. 6; pp. 633 - 643
• Main Authors: Li, Jihe, Yousefi, Keyvan, Ding, Wen, Singh, Jayanti, Shehadeh, Lina A
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.05.2017
• Subjects: Animals; Aorta - physiopathology; Aorta - surgery; Aptamers, Nucleotide - genetics; Aptamers, Nucleotide - metabolism; Arterial Pressure; Collagen Type III - metabolism; Cytokines - metabolism; Disease Models, Animal; Fibrosis; Gene Expression Regulation; Genetic Predisposition to Disease; Heart Failure - genetics; Heart Failure - metabolism; Heart Failure - physiopathology; Heart Failure - prevention & control; Hypertrophy, Left Ventricular - genetics; Hypertrophy, Left Ventricular - metabolism; Hypertrophy, Left Ventricular - physiopathology; Hypertrophy, Left Ventricular - prevention & control; Ligation; Lumican - metabolism; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Myocardium - metabolism; Myocardium - pathology; Original; Osteopontin - deficiency; Osteopontin - genetics; Osteopontin - metabolism; Phenotype; Phosphatidylinositol 3-Kinase - metabolism; Phosphorylation; Proto-Oncogene Proteins c-akt - metabolism; Signal Transduction; Time Factors; Ventricular Dysfunction, Left - genetics; Ventricular Dysfunction, Left - metabolism; Ventricular Dysfunction, Left - physiopathology; Ventricular Dysfunction, Left - prevention & control; Ventricular Function, Left; Ventricular Remodeling; Heart failure; Cardiac hypertrophy; Osteopontin; Cardiac fibrosis; Aptamer; TAC

Cardiac myocyte hypertrophy, the main compensatory response to chronic stress in the heart often progresses to a state of decompensation that can lead to heart failure. Osteopontin (OPN) is an effector for extracellular signalling that induces myocyte growth and fibrosis. Although increased OPN acti...