High-dose vitamin D3 supplementation is a requisite for modulation of skin-homing markers on regulatory T cells in HIV-infected patients

• Published in: AIDS research and human retroviruses Vol. 29; no. 2; p. 299
• Main Authors: Khoo, Ai-Leng, Koenen, Hans J P M, Michels, Meta, Ooms, Sharon, Bosch, Marjolein, Netea, Mihai G, Joosten, Irma, van der Ven, André J A M
• Format: Journal Article
• Language: English
• Published: United States 01.02.2013
• Subjects: Adult; Cholecalciferol - administration & dosage; Cohort Studies; Female; Flow Cytometry; Gene Expression; HIV Infections - immunology; HIV-1 - immunology; Humans; Immunologic Factors - administration & dosage; Integrins - biosynthesis; Male; Middle Aged; Pilot Projects; Receptors, CCR - biosynthesis; Receptors, CCR10 - biosynthesis; Receptors, CCR4 - biosynthesis; Skin - immunology; T-Lymphocytes, Regulatory - immunology; Young Adult

Vitamin D(3) is known to have an effect on the immune function. We investigated the immunomodulatory capability of vitamin D(3) in HIV-infected patients and studied the expression of chemokine receptors on regulatory T cells (Treg). Vitamin D(3)-deficient HIV-1-seropositive subjects were treated wit...