Small-Molecule Antiviral β-d-N4-Hydroxycytidine Inhibits a Proofreading-Intact Coronavirus with a High Genetic Barrier to Resistance

• Published in: Journal of virology Vol. 93; no. 24
• Main Authors: Agostini, Maria L, Pruijssers, Andrea J, Chappell, James D, Gribble, Jennifer, Lu, Xiaotao, Andres, Erica L, Bluemling, Gregory R, Lockwood, Mark A, Sheahan, Timothy P, Sims, Amy C, Natchus, Michael G, Saindane, Manohar, Kolykhalov, Alexander A, Painter, George R, Baric, Ralph S, Denison, Mark R
• Format: Journal Article
• Language: English
• Published: 1752 N St., N.W., Washington, DC American Society for Microbiology 15.12.2019
• Subjects: Vaccines and Antiviral Agents

Coronaviruses (CoVs) have emerged from animal reservoirs to cause severe and lethal disease in humans, but there are currently no FDA-approved antivirals to treat the infections. One class of antiviral compounds, nucleoside analogues, mimics naturally occurring nucleosides to inhibit viral replicati...