Recurrent stroke due to a novel voltage sensor mutation in Cav2.1 responds to verapamil

• Published in: Stroke (1970) Vol. 42; no. 2; pp. e14 - e17
• Main Authors: Knierim, Ellen, Leisle, Lilia, Wagner, Christiane, Weschke, Bernhard, Lucke, Barbara, Bohner, Georg, Dreier, Jens P, Schuelke, Markus
• Format: Journal Article
• Language: English
• Published: United States 01.02.2011
• Subjects: Ataxia; Calcium channels; Calcium channels (voltage-gated); Calcium Channels - genetics; Calcium Channels, N-Type - genetics; Calcium influx; Channel opening; Child; Children; Consciousness; Female; Fever; Genetic analysis; Head; Headache; Humans; Ischemia; Migraine; Mutation; Mutation - genetics; Paresis; Secondary Prevention; Sodium channels; Stroke; Stroke - drug therapy; Stroke - genetics; Stroke - prevention & control; Trauma; Verapamil; Verapamil - therapeutic use

Familial hemiplegic migraine is characterized by recurrent migraine, hemiparesis, and ataxia. Causes may be mutations in calcium and sodium channels or in a subunit of the Na/K-ATPse. Migraine treatment with calcium channel blockers was only successful in some patients. Summary of Case- We describe...