The relationship between anxiety and levels of Alzheimer's disease plasma biomarkers

Anxiety is highly prevalent in Alzheimer's disease (AD), correlating with CSF/PET biomarkers and disease progression. Relationships to plasma biomarkers are unclear. Herein, we compare levels of plasma biomarkers in research participants with and without anxiety at cognitively normal, mild cogn...

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Published inmedRxiv : the preprint server for health sciences
Main Authors Bernard, Mark A, Boutajangout, Allal, Debure, Ludovic, Ahmed, Wajiha, Briggs, Anthony Q, Boza-Calvo, Carolina, Vedvyas, Alok, Marsh, Karyn, Bubu, Omonigho M, Osorio, Ricardo S, Wisniewski, Thomas, Masurkar, Arjun V
Format Journal Article
LanguageEnglish
Published United States 10.07.2024
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Abstract Anxiety is highly prevalent in Alzheimer's disease (AD), correlating with CSF/PET biomarkers and disease progression. Relationships to plasma biomarkers are unclear. Herein, we compare levels of plasma biomarkers in research participants with and without anxiety at cognitively normal, mild cognitive impairment, and AD dementia stages. We observed significantly higher plasma tau/Aβ42 ratio in AD participants with anxiety versus those without, but did not observe differences at other stages or plasma biomarkers. No such relationships were evident with depression. These results support a unique pathophysiological relationship between anxiety and AD that can be reflected in plasma biomarkers, suggestive of heightened neurodegeneration.
AbstractList Anxiety is highly prevalent in Alzheimer's disease (AD), correlating with CSF/PET biomarkers and disease progression. Relationships to plasma biomarkers are unclear. Herein, we compare levels of plasma biomarkers in research participants with and without anxiety at cognitively normal, mild cognitive impairment, and AD dementia stages. We observed significantly higher plasma tau/Aβ42 ratio in AD participants with anxiety versus those without, but did not observe differences at other stages or plasma biomarkers. No such relationships were evident with depression. These results support a unique pathophysiological relationship between anxiety and AD that can be reflected in plasma biomarkers, suggestive of heightened neurodegeneration.
Author Debure, Ludovic
Wisniewski, Thomas
Boutajangout, Allal
Briggs, Anthony Q
Boza-Calvo, Carolina
Marsh, Karyn
Bernard, Mark A
Ahmed, Wajiha
Masurkar, Arjun V
Bubu, Omonigho M
Vedvyas, Alok
Osorio, Ricardo S
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Snippet Anxiety is highly prevalent in Alzheimer's disease (AD), correlating with CSF/PET biomarkers and disease progression. Relationships to plasma biomarkers are...
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