SARS-CoV-2 genomic surveillance identifies naturally occurring truncations of ORF7a that limit immune suppression

• Published in: medRxiv : the preprint server for health sciences
• Main Authors: Nemudryi, Artem, Nemudraia, Anna, Wiegand, Tanner, Nichols, Joseph, Snyder, Deann T, Hedges, Jodi F, Cicha, Calvin, Lee, Helen, Vanderwood, Karl K, Bimczok, Diane, Jutila, Mark, Wiedenheft, Blake
• Format: Journal Article
• Language: English
• Published: United States 10.03.2021
• Subjects: ORF7a; SARS-CoV-2; IFN response

Over 200,000 whole genome sequences of SARS-CoV-2 have been determined for viruses isolated from around the world. These sequences have been critical for understanding the spread and evolution of SARS-CoV-2. Using global phylogenomics, we show that mutations frequently occur in the C-terminal end of...