Receptor-mediated tobacco toxicity : Regulation of gene expression through α3β2 nicotinic receptor in oral epithelial cells

• Published in: The American journal of pathology Vol. 166; no. 2; pp. 597 - 613
• Main Authors: ARREDONDO, Juan, CHERNYAVSKY, Alexander I, MARUBIO, Lisa M, BEAUDET, Arthur L, JOLKOVSKY, David L, PINKERTON, Kent E, GRANDO, Sergei A
• Format: Journal Article
• Language: English
• Published: Bethesda, MD American Society for Investigative Pathology 01.02.2005
• Subjects: Biological and medical sciences; Investigative techniques, diagnostic techniques (general aspects); Medical sciences; Original Research Paper; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques; Tobacco, tobacco smoking; Toxicology; Cholinergic receptor; Anatomic pathology; Regulation(control); Tobacco; Toxicity; Tobacco smoking; Oral administration; Epithelial cell; Gene expression; Nicotinic receptor; Biological receptor

Tobacco is a known cause of oral disease but the mechanism remains elusive. Nicotine (Nic) is a likely culprit of pathobiological effects because it displaces the local cytotransmitter acetylcholine from the nicotinic receptors (nAChRs) expressed by oral keratinocytes (KCs). To gain a mechanistic in...