Voluntary alcohol intake alters the motivation to seek intravenous oxycodone and neuronal activation during the reinstatement of oxycodone and sucrose seeking

• Published in: bioRxiv
• Main Authors: Wilkinson, Courtney S, Blount, Harrison L, Davis, Shane, Rojas, Giselle, Wu, Lizhen, Murphy, Niall P, Schwendt, Marek, Knackstedt, Lori A
• Format: Journal Article
• Language: English
• Published: United States 24.07.2023

Opioid-alcohol polysubstance use is prevalent and worsens treatment outcomes. Here we assessed whether co-consumption of oxycodone and alcohol would influence intake of one another, demand for oxycodone, and the neurocircuitry underlying cue-primed reinstatement of oxycodone-seeking. Male and female...