Rules of engagement for condensins and cohesins guide mitotic chromosome formation

• Published in: bioRxiv : the preprint server for biology
• Main Authors: Samejima, Kumiko, Gibcus, Johan H, Abraham, Sameer, Cisneros-Soberanis, Fernanda, Samejima, Itaru, Beckett, Alison J, Pučeková, Nina, Abad, Maria Alba, Medina-Pritchard, Bethan, Paulson, James R, Xie, Linfeng, Jeyaprakash, A Arockia, Prior, Ian A, Mirny, Leonid A, Dekker, Job, Goloborodko, Anton, Earnshaw, William C
• Format: Journal Article
• Language: English
• Published: United States 30.04.2024

During mitosis, interphase chromatin is rapidly converted into rod-shaped mitotic chromosomes. Using Hi-C, imaging, proteomics and polymer modeling, we determine how the activity and interplay between loop-extruding SMC motors accomplishes this dramatic transition. Our work reveals rules of engageme...