VLK drives extracellular phosphorylation of EphB2 to govern the EphB2-NMDAR interaction and injury-induced pain

Phosphorylation of hundreds of protein extracellular domains is mediated by two kinase families, yet the significance of these kinases is underexplored. Here, we find that the presynaptic release of the tyrosine directed-ectokinase, Vertebrate Lonesome Kinase (VLK/Pkdcc), is necessary and sufficient...

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Bibliographic Details
Published inbioRxiv
Main Authors Srikanth, Kolluru D, Elahi, Hajira, Chander, Praveen, Washburn, Halley R, Hassler, Shayne, Mwirigi, Juliet M, Kume, Moeno, Loucks, Jessica, Arjarapu, Rohita, Hodge, Rachel, Shiers, Stephanie I, Sankaranarayanan, Ishwarya, Erdjument-Bromage, Hediye, Neubert, Thomas A, Campbell, Zachary T, Paik, Raehum, Price, Theodore J, Dalva, Matthew B
Format Journal Article
LanguageEnglish
Published United States 18.03.2024
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