CD11b suppresses TLR7-driven inflammatory signaling to protect against lupus nephritis

• Published in: bioRxiv
• Main Authors: Li, Xiaobo, Villanueva, Veronica, Jimenez, Viviana, Nguyen, Billy, Chauhan, Nishant Ranjan, Khan, Samia Q, Dorschner, Jessica M, Jensen, Mark A, Alzahrani, Khulood, Wei, Huiting, Cimbaluk, David J, Wei, David C, Jolly, Meenakshi, Lopez-Rodriguez, Darlah, Pineda, Santiago Balza, Barbosa, Antonio, Vazquez-Padron, Roberto I, Faridi, Hafeez M, Reiser, Jochen, Niewold, Timothy B, Gupta, Vineet
• Format: Journal Article
• Language: English
• Published: United States Cold Spring Harbor Laboratory 26.07.2024

Lupus Nephritis (LN) is a severe complication of systemic lupus erythematosus (SLE) that affects kidney function. Here, we investigated the role of CD11b, a protein encoded by the gene, in the development of LN and its functional activation as a therapeutic strategy. Genetic coding variants of signi...