Molecular basis of pituitary development defects

• Published in: Tunisie Medicale Vol. 85; no. 12; p. 999
• Main Authors: Turki, Zinet Marrakchi, Hamaoui, Raja Ben Belgacem, Ben Slama, Claude
• Format: Journal Article
• Language: English
• Published: Tunisia 01.12.2007
• Subjects: Animals; Cell Lineage; Disease Models, Animal; Gene Expression; Humans; Hypopituitarism - congenital; Hypopituitarism - embryology; Hypopituitarism - genetics; Infant; Infant, Newborn; Mice; Mice, Knockout; Mutation; Phenotype; Pituitary Gland, Anterior - cytology; Pituitary Gland, Anterior - embryology; Pituitary Gland, Anterior - growth & development; Transcription Factor Pit-1 - genetics; Transcription Factors - genetics

Over the last twenty years, the progress made in molecular biology have led to the identification of many transcription factor genes, whose mutations has been reported as causes of familial hypopituitarism. Based on a literature review, this study is intending to highlight the role of some transcrip...