Ligament injury in adult zebrafish triggers ECM remodeling and cell dedifferentiation for scar-free regeneration

• Published in: bioRxiv
• Main Authors: Anderson, Troy, Mo, Julia, Gagarin, Ernesto, Sherwood, Desmarie, Blumenkrantz, Maria, Mao, Eric, Leon, Gianna, Chen, Hung-Jhen, Tseng, Kuo-Chang, Fabian, Peter, Crump, J Gage, Smeeton, Joanna
• Format: Journal Article
• Language: English
• Published: United States 04.02.2023

After traumatic injury, healing of mammalian ligaments is typically associated with fibrotic scarring as opposed to scar-free regeneration. In contrast, here we show that the ligament supporting the jaw joint of adult zebrafish is capable of rapid and complete scar-free healing. Following surgical t...