Test–retest reproducibility of human brain multi‐slice 1H FID‐MRSI data at 9.4T after optimization of lipid regularization, macromolecular model, and spline baseline stiffness

• Published in: Magnetic resonance in medicine Vol. 89; no. 1; pp. 11 - 28
• Main Authors: Ziegs, Theresia, Wright, Andrew Martin, Henning, Anke
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc 01.01.2023
• Subjects: Brain; Brain mapping; Brain slice preparation; Cerebrum; Choline; Coefficient of variation; Creatine; Glutamine; Glutathione; human brain; lipid regularization; Lipids; Lower bounds; Macromolecules; magnetic resonance imaging; Mathematical analysis; Metabolites; Optimization; Regularization; Reproducibility; Stiffness; Substantia alba; Taurine; ultra‐high field strengths; whole‐brain MRSI

Purpose This study analyzes the effects of retrospective lipid suppression, a simulated macromolecular prior knowledge and different spline baseline stiffness values on 9.4T multi‐slice proton FID‐MRSI data spanning the whole cerebrum of human brain and the reproducibility of respective metabolite r...