Evolutionary Dynamics of a Population of Cells with a Toxin Suppressor Gene

• Published in: Transactions on Computational Systems Biology XIII Vol. 6575; pp. 1 - 12
• Main Authors: Häkkinen, Antti, Biddle, Fred G., Smolander, Olli-Pekka, Yli-Harja, Olli, Ribeiro, Andre S.
• Format: Book Chapter
• Language: English
• Published: Germany Springer Berlin / Heidelberg 2011; Springer Berlin Heidelberg
• Series: Lecture Notes in Computer Science
• Subjects: High Mutation Rate; Mutation Rate; Neutral Mutation; Noise Strength; Stochastic Simulation Algorithm

Environmental changes are known to trigger evolutionary changes, e.g. by favoring higher mutation rates. We study the evolutionary dynamics of a delayed stochastic genetic circuit using a simulator developed for this aim. We model a cell population subject to selection and environmental changes. Eac...